Fallopian Tube Pathology

• Ki67 LOW (<5%)

• P53 will show patchy weak positivity

• Absence of mitotic figures, apoptosis, prominent nucleoli or loss of polarity

  • Don't confuse intraepithelial lymphocytes for apoptotic bodies!​

• Dilated, slit-like spaces

• Looks like an intraductal papilloma of the breast at low power

• Typical histology

  • Endometrial glands​

  • Dense stroma surrounding glands

  • Extravasated RBCs

  • +/- hemosiderin

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- SEE MORE VIRTUAL SLIDES -

• Acute vs. Chronic Salpingitis

• Granulomatous (TB, Sarcoidosis)

• Pelvic Inflammatory Disease (Chlamydia or Gonorrhea)

• Other

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<-- Click to examine this slide demonstrating chronic salpingitis from schistosomiasis infection. How neat!?!

• Most often in fallopian tube

• Clinical pic= +/- hx of PID, Amenorrhea, Vaginal bleeding, Pain

• Diagnosis =  elevated/abnormal HCG levels & ultrasound

• D&C (of endometrium) would NOT have fetal parts

• Requires emergency surgery 

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<-- Click to examine this slide demonstrating an ectopic tubal gestation. Notice the chorionic villi present and abundant hemorrhage from rupture of the tube.

• Primary tumors of FT are very RARE!

• Exclude extension or metastases from endometrium or ovary!​

• Serous Tubal Intraepithelial Lesion/Carcinoma (STIL/STIC)

• RFs= BRCA gene mutn, SCOUT lesions (PAX2 loss; cellular outgrowths in whole FT)

• Most common in fimbriated end of FT- sample extensively during grossing!​

• Elongated, hyperchromatic nuclei with mitosis & apoptosis

• Helpful stains=

  • P53+ (either strongly diffusely positive or completely negative)

    • Wild type (normal) shows patchy, weak positivity​

  • Ki67 inc