Head and Neck Pathology
Cardiovascular
An Overview of
Cardiovascular Topics...
Transplant Pathology
Vasculitis
Ischemic Heart Disease
Cardiomyopathy
Valvular Heart Disease
Tumors
Myocarditis & Infections
Other
Transplant Pathology
Grading System
Download this open access article from the American Heart Association for full details of antibody mediated rejection
Hyperacute vs. Acute
I'm a paragraph. Click here to add your own text and edit me. It's easy.
Quilty Lesion
I'm a paragraph. Click here to add your own text and edit me. It's easy.
TIMING:
-
Immediately or within hours after transplant
HISTOLOGIC CLUES:
-
Nonspecific changes
-
Hemorrhage
-
Edema
-
Platelet aggregates in vessels
-
Eventually, PMNs come in and are seen
HIGH YIELD FACTOIDS
-
Lymphocytes, Macrophages and Eosinophils
-
DDx of Eos: Drug rxn, toxoplasmosis, CMV
-
-
NO Neutrophils (PMNs)
-
(can be seen with ischemia, antibody-mediated rejection, or infection)
-
-
NO plasma cells!!
-
(if present = Quilty lesion or PTLD)
-
HIGH YIELD FACTOIDS
-
Capillary injury
-
Endothelial swelling
-
Intravascular macrophages
-
Edema
-
Hemorrhage
-
PMNs near capillaries
-
Thrombi
-
Myocyte necrosis
-
IgG, IgM, IgA, C3d, C4d, C1q